abstract：OBJECTIVE:To study effects of microRNA-98 (miR-98) on osteogenic differentiation of mesenchymal stem cells (MSCs). PATIENTS AND METHODS:We predicted target gene of miR-98 with software test, and detected expression changes of miR-98, as well as its target gene HMGA2, in the process of osteogenic differentiation of mes...

journal_title：European review for medical and pharmacological sciences

authors： Gao XL,Cao MG,Ai GG,Hu YB

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To investigate the correlations of serum vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) levels with colorectal liver metastasis (CLM) in patients with colorectal cancer (CRC), and determine the effects of transhepatic arterial chemoembolization (TACE) on their expressions. P...

journal_title：European review for medical and pharmacological sciences

authors： Xu H,Ren YJ,Liu K,Min XL,Yang L,Zhou Y,Zheng J,Yang C

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of hyperbaric oxygen preconditioning (HBO-PC) on neuronal apoptosis, Ca2+ concentration, and Caspases expression after spinal cord injury (SCI) in rats. MATERIALS AND METHODS:A total of 36 rats were randomly divided into control group (CON group), hyperbaric oxygen preconditioning ...

journal_title：European review for medical and pharmacological sciences

authors： Pan JY,Cai RX,Chen Y,Li Y,Lin WW,Wu J,Wang XD

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:This paper aims at screening the common differential genes of coronary atherosclerotic heart disease (CAD) and ischemic cardiomyopathy (ICM), and to conduct pathway analysis and protein-protein interaction (PPI) network analysis for the differential genes. MATERIALS AND METHODS:The CAD and ICM datasets were ...

journal_title：European review for medical and pharmacological sciences

authors： Li GM,Zhang CL,Rui RP,Sun B,Guo W

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Osteosarcoma (OS) is a kind of malignant bone tumor. The aim of the manuscript is to investigate the clinical significance and the functional effects of long non-coding (lncRNA) colon cancer-associated transcript 2 (CCAT2) in osteosarcoma. PATIENTS AND METHODS:Expression of CCAT2 was detected by quantitative...

journal_title：European review for medical and pharmacological sciences

authors： Ruan R,Zhao XL

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Circular RNAs are a subgroup of non-coding RNAs and generated by a mammalian genome. The purpose of this study was to investigate the clinical significance, biological function and molecular mechanism of circ_0067934 in human non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We assayed expression leve...

journal_title：European review for medical and pharmacological sciences

authors： Wang J,Li H

更新日期：2018-05-01 00:00:00

abstract：:The current case report is about spontaneous non-traumatic rupture of a splenic artery aneurysm (SAA) in a 53-year-old woman with no particular medical history. An emergent laparotomy with splenectomy was required, unfortunately without success as the patient died. SAA is the most common visceral artery aneurysm. Most...

journal_title：European review for medical and pharmacological sciences

authors： Martin D,Teixeira Farinha H,Dattner N,Rotman S,Demartines N,Sauvain MO

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Melatonin (MT) is a hormone mainly produced by the pineal gland. It may be involved in the regulation of nociception, the mechanisms of which remain unclear. In the present study, electrophysiological effects of MT on neurons were studied. MATERIALS AND METHODS:The cultured neurons were isolated from Sprague...

journal_title：European review for medical and pharmacological sciences

authors： Huang F,Guan XY,Yan Y,Fan WG,You YY,He HW,Cheng B

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To investigate the correlations of inflammatory factors, interleukin-6 (IL-6), IL-10, IL-13 and tumor necrosis factor-α (TNF-α), and composition of bacterial flora in the peritoneal fluid with infertility in endometriosis patients. PATIENTS AND METHODS:A total of 55 patients diagnosed with endometriosis and ...

journal_title：European review for medical and pharmacological sciences

authors： Wang XM,Ma ZY,Song N

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To investigate the expression of G-quadruplex antibody BG4 in human gastric cancer AGS cells and assess its functions in attenuating proliferation and promoting apoptosis in gastric cancer. MATERIALS AND METHODS:BG4 high-expression gastric cancer AGS cell line was established by pEGFP-N1-BG4 transient transf...

journal_title：European review for medical and pharmacological sciences

authors： Zhang YQ,Pei JH,Shi SS,Zheng J,Wang JM,Guo XS,Cui GY,Wang XY,Zhang HP,Hu WQ

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To explore the expression and function of insulin-like growth factor II (IGFII) mRNA binding protein (IMP3) in the Triple Negative Breast Cancer (TNBC). MATERIALS AND METHODS:According to previously reported gene expression array, we found that IMP3 had significantly higher expression in the CD44+CD24-ESA+ c...

journal_title：European review for medical and pharmacological sciences

authors： Huang QD,Zheng SR,Cai YJ,Chen DL,Shen YY,Lin CQ,Hu XQ,Wang XH,Shi H,Guo GL

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether SENP3 protects H9C2 cells from apoptosis triggered by H/R through the signal transducer and activator of transcription 3 (STAT3) pathway. MATERIALS AND METHODS:Male C57BL mice were cultured and mouse models of myocardial I/RI were established. At the same time, cardiomyoblast H9C2 cell...

journal_title：European review for medical and pharmacological sciences

authors： Zhang Y,Zheng LM,Wang CX,Gu JM,Xue S

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of miR-519d on the 5-fluorouracil resistance in colorectal cancer cells and to explore the mechanism. MATERIALS AND METHODS:Colorectal cancer cells HCT116 and SW480 were transfected with miR519d-mimic or siCCND1 by transient transfection. The sensitivity of cells to 5-Fu was assaye...

journal_title：European review for medical and pharmacological sciences

authors： Huang R,Lin JY,Chi YJ

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:This study explores the possible relation between cervical infections with Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) and the occurrence of recurrent spontaneous abortion (RSA). PATIENTS AND METHODS:132 patients with RSA (observation group) and 96 normal pregnancy volunteers undergoing planned a...

journal_title：European review for medical and pharmacological sciences

authors： Cao CJ,Wang YF,Fang DM,Hu Y

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:LncRNAs participate in the proliferation, apoptosis, and invasion of colorectal cancer. We aimed at investigating the uncovered effect of lncRNALUADT1 on colorectal cancer. PATIENTS AND METHODS:The relative expression level of lncRNALUADT1 in tumor specimen was tested by Real-time quantitative PCR. The assoc...

journal_title：European review for medical and pharmacological sciences

authors： Zhang XF,Zhang Y,Shen Z,Yang GG,Wang HD,Li LF,Liu DC,Qiu JM

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of miR-146a gene silencing on brain tissue and related drug-resistance proteins in rats and explore its resistance mechanism. MATERIALS AND METHODS:A rat model of chronic refractory epilepsy was established. The rats were divided into four groups: Normal group, Model group, Negative...

journal_title：European review for medical and pharmacological sciences

authors： Zhang HL,Lin YH,Qu Y,Chen Q

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To explore a new approach for treating renal insufficiency with gene therapy by implanting decorin (DCN)-expressing fibroblasts within the renal tissue of rats with renal failure to neutralize TGF-β1 activity. MATERIALS AND METHODS:The 5/6 kidney of the selected male SD rats were removed under aseptic condit...

journal_title：European review for medical and pharmacological sciences

authors： Li R,Wang QF,Li WW,Niu XC

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:PI3K/AKT/mTOR pathway plays important roles in tumor pathogenesis. mTOR is up-regulated and miR-214 is down-regulated in cervical can-*cers. This study investigated whether miR-214 regulated mTOR expression and affected cervical cancer cell proliferation, apoptosis or invasion. PATIENTS AND METHODS:Cervical ...

journal_title：European review for medical and pharmacological sciences

authors： Wang F,Tan WH,Liu W,Jin YX,Dong DD,Zhao XJ,Liu Q

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Laryngeal cancer is a common malignant tumor in the head and neck, which affects swallowing, breathing, and pronunciation function. In recent years, many long non-coding RNAs (lncRNAs) have been shown to be involved in the progression of cancer with the development of gene sequencing, transcriptomics, and bio...

journal_title：European review for medical and pharmacological sciences

authors： Xie ZZ,Xiao ZC,Song YX,Li W,Tan GL

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To compare the placental exosome levels of normal pregnant women and pregnant women with gestational diabetes mellitus (GDM) in different gestational stages, and further investigate the effects of exosomes on the release of cytokines from human umbilical vein endothelial cells. PATIENTS AND METHODS:20 pregna...

journal_title：European review for medical and pharmacological sciences

authors： Liu J,Wang SZ,Wang QL,Du JG,Wang BB

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore whether Dl-3-n-butylphthalide (DBT) could protect blood-brain barrier (BBB) of mice with experimental cerebral infarction and the relevant mechanism. MATERIALS AND METHODS:Adult male CD-1 mice were selected as the study objects. The permanent middle cerebral artery occlus...

journal_title：European review for medical and pharmacological sciences

authors： Zhao YJ,Nai Y,Ma QS,Song DJ,Ma YB,Zhang LH,Mi LX

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Extracellular signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signal pathway participates in cell proliferation, cycle, and apoptosis. MiR-16 is down-regulated in the pituitary tumor. This study investigated the role and related mechanism of miR-16 on pituitary tumor proliferation, cycle...

journal_title：European review for medical and pharmacological sciences

authors： Wang DW,Wang YQ,Shu HS

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Aberrant activation of (Wingless and mouse homolog Int-1) Wnt/β-catenin signaling pathways closely involved in the occurrence and progression of several types of human malignancies. This research was undertaken to elucidate the important role of (Wingless and mouse homolog Int-1) in lung cancer. PATIENTS AND...

journal_title：European review for medical and pharmacological sciences

authors： Xing Z,Wang HY,Su WY,Liu YF,Wang XX,Zhan P,Lv TF,Song Y

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Traumatic lung injury (TLI) can cause inflammation and oxidative stress, or even leads to acute respiratory distress syndrome (ARDS) and death. Nuclear factor erythroid-2 related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signal pathway participates in disea...

journal_title：European review for medical and pharmacological sciences

authors： Hu LY,Cui JB,Xu XM,Huang ZH,Jiao HT

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Orolingual angioedema (OA) is a rare clinical complication with a potentially fatal risk that occurs after the intravenous application of alteplase (rt-PA) in patients with acute ischemic stroke. The purpose of this work is to investigate the related factors of OA in patients with acute ischemic stroke after ...

journal_title：European review for medical and pharmacological sciences

authors： Wang YX,Li YQ,Chen Y,Zhang CH,Dong Z,Wang Z,Zhao SN,Li CH,Zhang PL

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:This study sought to investigate the expression of interferon-λ2 (IFN-λ2) in patients with combined allergic rhinitis and nasal polyps (AR+NP), analyze the correlation between IFN-λ2 and tryptase, interleukin 10 (IL-10), and interleukin 12 (IL-12), and identify its peripheral blood cell origins. PATIENTS AND...

journal_title：European review for medical and pharmacological sciences

authors： Wang YT,Wang H,Wang FL,Qian XM,Zhuang SF,Yang MX,Liu CX

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The ubiquitin-conjugating enzyme E2C (UBE2C) has been known as a crucial factor upregulated in various tumors. The functions of UBE2C is mainly involved in the pathway protein ubiquitination. This study investigates the expression of UBE2C in gastric cancers and its correlation with overall survival rate. MA...

journal_title：European review for medical and pharmacological sciences

authors： Zhang HQ,Zhao G,Ke B,Ma G,Liu GL,Liang H,Liu LR,Hao XS

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:MicroRNAs (miRNAs) are now recognized as important regulators of gene expression. The aim of the study was to investigate the role of miR-146b-5p in the TLR4 pathway and provide the basis for the treatment of lupus nephritis. MATERIALS AND METHODS:The glomerular mesangial cells were cultured in vitro and div...

journal_title：European review for medical and pharmacological sciences

authors： Sheng ZX,Yao H,Cai ZY

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Hemorrhagic shock is a common vital condition in obstetrics, and major treatment consists of bleeding control and liquid resuscitation. MicroRNA (miR) has been found to regulate multiple diseases. However, its expression profile in hemorrhagic shock or effects on the ischemia-reperfusion injury in pregnant mi...

journal_title：European review for medical and pharmacological sciences

authors： Qin LB,Li ZY,Li H,Fan XQ,Liu HG,Dong XM,Jia WY

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To determine the expression of neutrophil gelatinase-associated lipocalin (NGAL) and vascular endothelial growth factor (VEGF) in endometrial carcinoma. PATIENTS AND METHODS:The clinical features (FIGO staging, pathological type, differentiation level, myometrial invasion depth and tumor size) and immunostai...

journal_title：European review for medical and pharmacological sciences

authors： Xu H,Sun X,Sun WJ

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To investigate the safety and effectiveness of the application of high-volume hemofiltration (HVHF) in children with sepsis combined with acute kidney injury. PATIENTS AND METHODS:A total of 76 child patients were enrolled and randomly divided equally (n=38) into control and the observation groups respective...

journal_title：European review for medical and pharmacological sciences

authors： Meng SQ,Yang WB,Liu JG,Yuan JY,Zhang K,Ding WY,Yang SQ,Liu JH

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Primary liver cancer is a sort of the most common solid tumors occurred in the digestive system. The incidence and mortality rate maintain at a high level, thus leading to heavy economic and psychological burdens for patients. Next-generation biological therapy, such as cellular immune treatment, improves the...

journal_title：European review for medical and pharmacological sciences

authors： He W,Huang Z,Zhou S,Huang L,Wang B,Zhu L,Ding Y,Yu YL,Zhang S

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To observe the effect of cisplatin-induced autophagy in human ovarian cancer cell lines and explore the correlation between RP11-135L22.1 with cisplatin-induced autophagy. MATERIALS AND METHODS:Genome-wide expression profile and chemotherapy sensitivity data of ovarian cancer were downloaded from TCGA databa...

journal_title：European review for medical and pharmacological sciences

authors： Zou SH,Du X,Sun FD,Wang PC,Li M

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Lung cancer is one of the most common malignancies worldwide, the morbidity and mortality of which have been on rising in recent years. Moreover, lncRNAs have been implicated in the development of various cancers, as well as cancer treatment and prognosis. In this study, long non-coding RNA (lncRNA) MEG3, an ...

journal_title：European review for medical and pharmacological sciences

authors： Xia H,Qu XL,Liu LY,Qian DH,Jing HY

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Hypoxia/reoxygenation (H/R)-induced cardiomyocyte apoptosis plays a critical role in the development of myocardial infarction. Che-1 has been reported as an anti-apoptotic gene in response to various cellular stresses. However, whether Che-1 regulates cardiomyocyte apoptosis in myocardial infarction remains u...

journal_title：European review for medical and pharmacological sciences

authors： Wang D,Chen TY,Liu FJ

更新日期：2018-02-01 00:00:00

abstract：:This review illustrates some brief considerations of the medical use of cannabis recently issued in Italy. History and uses of cannabis throughout centuries and different countries are illustrated together with a description of botany and active phytocannabinoids. Then, medical use of cannabis anti-pain treatment for ...

journal_title：European review for medical and pharmacological sciences

authors： Zaami S,Di Luca A,Di Luca NM,Montanari Vergallo G

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Long noncoding RNA (lncRNA) GIHCG has been reported as an oncogene in hepatocellular carcinoma. However, the expression, roles, and clinical values of GIHCG in renal cell carcinoma (RCC) remain unclear. The aim of this study was to investigate the expression, roles, diagnostic and prognostic values of GIHCG i...

journal_title：European review for medical and pharmacological sciences

authors： He ZH,Qin XH,Zhang XL,Yi JW,Han JY

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To investigate the correlations of the computed tomography (CT) signs of non-small cell lung cancer (NSCLC) with pathological features and the expression levels of phosphoprotein 53 (p53) and c-Myc in patients. PATIENTS AND METHODS:87 patients with NSCLC admitted to the Department of Oncology in our hospital...

journal_title：European review for medical and pharmacological sciences

authors： Li HS,Lv RQ,Liu L

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Pain relief is a very important aspect in Pediatrician's clinical practice. It is often thought that young children, particularly infants, do not perceive as much pain as adults because of their immature nervous system and that untreated pain would not have adverse long-term consequences. Instead, it has been...

journal_title：European review for medical and pharmacological sciences

authors： Fantacci C,Fabrizio GC,Ferrara P,Franceschi F,Chiaretti A

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Cervical cancer severely threatens patients' lives. MicroRNAs contribute to regulatory function in the growth and apoptosis of cells. The present study investigated the effect of miRNA211 on growth and apoptosis of cervical cancer SiHa cells. MATERIALS AND METHODS:miRNA211 and control miRNA were synthesized ...

journal_title：European review for medical and pharmacological sciences

authors： Liu YL,Wang GQ,Cui HX,Li XX,Xu ZL,Wang XY

更新日期：2018-01-01 00:00:00